Small-Molecule-Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging
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چکیده
منابع مشابه
Small-Molecule Hydrophobic Tagging Induced Degradation of HaloTag Fusion Proteins
The ability to regulate any protein of interest in living systems with small molecules remains a challenge. We hypothesized that appending a hydrophobic moiety to the surface of a protein would mimic the partially denatured state of the protein, thus engaging the cellular quality control machinery to induce its proteasomal degradation. We designed and synthesized bifunctional small molecules to...
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ژورنال
عنوان ژورنال: Angewandte Chemie International Edition
سال: 2015
ISSN: 1433-7851
DOI: 10.1002/anie.201503720